Trp-ing upon new repressors
نویسندگان
چکیده
منابع مشابه
Diet and Genetics: Trp-ing Over Food Sensitivity
Laboratory-reared Caenorhabditis elegans eat Escherichia coli. A new study demonstrates a strong diet-gene interaction: worms with reduced nhr-114 activity are fertile when fed E. coli K-12 strains but are sterile on E. coli B. Surprisingly, tryptophan supplementation of E. coli B restores worm fertility.
متن کاملTRP-ing Down the Path to Insulin Secretion
The means by which glucose stimulates insulin secretion from pancreatic -cells has been studied for decades. Yet we still do not fully understand the cellular machinery underlying this process, the complexity of which continues to surprise. The triggering pathway for glucose-induced insulin secretion is generally well described, and the current model, shown on the left-side of Fig. 1, has been ...
متن کاملIntragenic complementation between Escherichia coli trp repressors with different defects in the tryptophan-binding pocket.
Site-directed mutagenesis of the trpR gene (encoding the trp repressor, TrpR) was used to replace Gly85 with tryptophan (Trp or W), in order to place Trp near its normal location in the L-tryptophan(L-W)-binding pocket. The resulting mutant protein (G85W) exhibits weak, but significant repressor activity in vivo that is independent of the presence of L-W in the media. This mutant negatively com...
متن کاملThe Influence of Thyroid Feeding upon Poison- Ing by Acetonitrile
Speculation as to the functions of the thyroid glands has taken two main directions: some suppose that these organs elaborate an internal secretion which is of itself necessary for certain processes of metabolism, while others think that their chief function is to neutralize poisonous substances originating in the body (“enterotoxines”) or introduced into it from without (iodine, for example). ...
متن کاملRepressors
Jacques Monod and Francois Jacob, our heroes, described a gene-regulatory world run exclusively by repressors. The activities of repressors, their abilities to bind DNA as we later learned, would be controlled — helped or hindered — by small molecules that bind these proteins. They showed [1] that networks of considerable complexity could be created with such a regulatory system. There was no n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2018
ISSN: 1552-4450,1552-4469
DOI: 10.1038/s41589-018-0012-9